منابع مشابه
Update on Cyclotron Production Studies of No-carrier- Added: Copper-64, Astatine-211/polonium-211g, Rhenium-186g
Selected results are presented and discussed concerning nuclear data relevant to the production of innovative medical radionuclides (RNs) of special interest, measurements of excitation functions of the involved nuclear reactions, in comparison with the corresponding theoretical calculations. Moreover, at the Radiochemistry Laboratory of Accelerators and Applied Superconductivity Laboratory, LA...
متن کاملAutomated astatination of biomolecules – a stepping stone towards multicenter clinical trials
To facilitate multicentre clinical studies on targeted alpha therapy, it is necessary to develop an automated, on-site procedure for conjugating rare, short-lived, alpha-emitting radionuclides to biomolecules. Astatine-211 is one of the few alpha-emitting nuclides with appropriate chemical and physical properties for use in targeted therapies for cancer. Due to the very short range of the emitt...
متن کاملCondensed astatine: monatomic and metallic.
The condensed matter properties of the nominal terminating element of the halogen group with atomic number 85, astatine, are as yet unknown. In the intervening more than 70 years since its discovery significant advances have been made in substrate cooling and the other techniques necessary for the production of the element to the point where we might now enquire about the key properties astatin...
متن کاملRadiopharmaceuticals: Production and Availability
1. The use of specific radiotracers called radiopharmaceuticals for imaging organ function and disease states is a unique capability of nuclear medicine. Unlike other imaging modalities such as Computed Tomography (CT), Magnetic Resonance Imaging (MRI) and Ultrasonography (US), nuclear medicine procedures are capable of mapping physiological function and metabolic activity and thereby giving mo...
متن کاملTranscriptional response of BALB/c mouse thyroids following in vivo astatine-211 exposure reveals distinct gene expression profiles
BACKGROUND Astatine-211 (211At) is an alpha particle emitting halogen with almost optimal linear energy transfer for creating DNA double-strand breaks and is thus proposed for radionuclide therapy when bound to tumor-seeking agents. Unbound 211At accumulates in the thyroid gland, and the concept of basal radiation-induced biological effects in the thyroid tissue is, to a high degree, unknown an...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Radiopharmaceuticalse
سال: 2011
ISSN: 1874-4710
DOI: 10.2174/1874471011104030177